abstract：BACKGROUND:Multiple sclerosis can cause cardiovascular autonomic dysfunction. It is assumed that is caused by multiple demyelinating plaques localized in the brain stem and spinal cord. Previous studies have determined this using tilt table test, heart rate responses to Valsalva maneuver and deep breathing and heart ra...

journal_title：Multiple sclerosis and related disorders

authors： Damla O,Altug C,Pinar KK,Alper K,Dilek IG,Kadriye A

更新日期：2018-08-01 00:00:00

abstract：:Acquired demyelinating CNS syndromes include a broad spectrum of clinical phenotypes and different entities can overlap. Therefore, differential diagnosis is still challenging. A humoral immune reaction against myelin oligodendrocyte glycoprotein (MOG) is present in a subgroup of these patients, particularly in childr...

journal_title：Multiple sclerosis and related disorders

authors： Di Pauli F,Reindl M,Berger T

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Literature regarding MS epidemiology and phenotype is scarce but has increased markedly over the past years. The objective of the present work is to assess the evolution of the prevalence and phenotype of MS in Latin America during recent years. METHODS:Review of literature. RESULTS:MS prevalence levels ar...

journal_title：Multiple sclerosis and related disorders

authors： Negrotto L,Correale J

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:The dual task paradigm (the simultaneous performance of motor and cognitive task) is used in a laboratory setting to evaluate walking impairments that affect patients' daily lives. Although promising, it is poorly standardized and neither the cognitive task nor the motor task have been validated in a matched...

journal_title：Multiple sclerosis and related disorders

authors： Coghe G,Pilloni G,Zucca E,Porta M,Corona F,Frau J,Fenu G,Lorefice L,Marrosu MG,Pau M,Cocco E

更新日期：2018-05-01 00:00:00

abstract：:A 34-year old Caucasian female was initially diagnosed with multiple small-vessel strokes at age 20 years which were etiologically classified as secondary to anti-phospholipid antibody syndrome (APS) although she had no history or laboratory data to suggest APS. Based on her MRI of brain findings, one of her neurologi...

journal_title：Multiple sclerosis and related disorders

authors： Avasarala JR,Jones JR,Rogers CR

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is a common chronic neurological disease that causes disability. MS can have various clinical manifestations, one of which is olfactory dysfunction. In clinical practice, olfactory disturbances are usually underdiagnosed. The aim of our study is to assess olfactory function and its re...

journal_title：Multiple sclerosis and related disorders

authors： Atalar AÇ,Erdal Y,Tekin B,Yıldız M,Akdoğan Ö,Emre U

更新日期：2018-04-01 00:00:00

abstract：:Fingolimod, taken orally once per day, is approved for the treatment of relapsing-remitting multiple sclerosis (MS). It should be stopped at least two months before conception as it is not considered safe during pregnancy or when breast feeding. In vitro and animal studies have found a possibly increased risk of conge...

journal_title：Multiple sclerosis and related disorders

authors： Navardi S,Sahraian MA

更新日期：2018-04-01 00:00:00

abstract：IMPORTANCE:Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by relapses and a progressive course that may lead to accumulation of physical and cognitive disability. Cognitive training interventions seem to improve the cognitive performance of MS patients. The aim of ...

journal_title：Multiple sclerosis and related disorders

authors： Dardiotis E,Nousia A,Siokas V,Tsouris Z,Andravizou A,Mentis AA,Florou D,Messinis L,Nasios G

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The 2015 International Panel for neuromyelitis optica (NMO) spectrum disorders (NMOSD) diagnosis (IPND) criteria was recently proposed. However, because there are no studies evaluating application of the IPND criteria in Latin American populations, we aimed to assess whether these new criteria improve the di...

journal_title：Multiple sclerosis and related disorders

authors： Carnero Contentti E,Soto de Castillo I,Daccach Marques V,López PA,Antunes Barreira A,Armas E,de Aquino Cruz C,Rubstein A,Lavigne Moreira C,Molina OM,Soto A,Tkachuk V

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The corpus callosum index (CCI) can be easily and reliably obtained from conventional magnetic resonance imaging (MRI) and has been proposed as a possible marker of brain atrophy in MS. However, further validation of its correlation with volumetric measurements is still warranted. OBJECTIVE:To assess the co...

journal_title：Multiple sclerosis and related disorders

authors： Gonçalves LI,Dos Passos GR,Conzatti LP,Burger JLP,Tomasi GH,Zandoná MÉ,Azambuja LS,Gomes I,Franco A,Sato DK,Becker J

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To analyze the changes in retinal nerve fiber layer (RNFL) in eyes with and without prior history of optic neuritis (ON) of patients with multiple sclerosis (MS) after a 5-year time period (2010-2015) using optical coherence tomography. METHODS:The RNFL thickness of 114 eyes of 57 MS patients and 40 eyes of 20...

journal_title：Multiple sclerosis and related disorders

authors： Abalo-Lojo JM,Treus A,Arias M,Gómez-Ulla F,Gonzalez F

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Severe relapses that required treatment were important outcomes in the sentinel trials of disease-modifying therapy (DMT). Identifying such relapses in administrative data would allow comparative-effectiveness studies of DMTs to be conducted in real-world clinical settings. METHODS:All relapsing-remitting (...

journal_title：Multiple sclerosis and related disorders

authors： Marriott JJ,Chen H,Fransoo R,Marrie RA

更新日期：2018-01-01 00:00:00

abstract：:Multiple Sclerosis (MS) is an autoimmune disease in which lymphocytes target putative myelin antigens in the CNS, causing inflammation and neurodegeneration. Fingolimod (FTY720) is an immunosuppressive drug used as a second line therapy for relapsing forms of MS due to its safety profile and good response to treatment...

journal_title：Multiple sclerosis and related disorders

authors： Enriquez-Marulanda A,Valderrama-Chaparro J,Parrado L,Diego Vélez J,Maria Granados A,Luis Orozco J,Quiñones J

更新日期：2017-11-01 00:00:00

abstract：:Fibrinogen is a protein that plays a key role in blood coagulation and thrombosis and it is involved in several inflammatory processes; in multiple sclerosis (MS) may be related with blood-brain barrier (BBB) disruption. We analysed the relationship between plasma fibrinogen levels and the presence of active lesions o...

journal_title：Multiple sclerosis and related disorders

authors： Miranda Acuña J,Hidalgo de la Cruz M,Ros AL,Tapia SP,Martínez Ginés ML,de Andrés Frutos CD

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Multiple reports have described the proportion of Th17 cells in peripheral blood and serum levels of Th17-related cytokines in patients with multiple sclerosis (MS). To clarify the status of Th17 cells and Th17-related cytokines in MS patients, we did a meta-analysis of the results published previously to as...

journal_title：Multiple sclerosis and related disorders

authors： Li YF,Zhang SX,Ma XW,Xue YL,Gao C,Li XY

更新日期：2017-11-01 00:00:00

abstract：:Neurosarcoidosis is a rare disease with various clinical phenotypes. Thus, case reports and series broaden the understanding of this entity (Ibitoye et al., 2017). We present a case of isolated intramedullary spinal cord sarcoidosis, an exceedingly rare phenotype, which needs to be distinguished especially from neurom...

journal_title：Multiple sclerosis and related disorders

authors： Graf J,Ringelstein M,Aktas O,Wattjes MP,Hartung HP

更新日期：2017-11-01 00:00:00

abstract：:Neuromyelitis optica is a severe autoimmune demyelinating disease; however, the trigger for autoimmunity in an individual patient is unclear. Here, we report the case of a 48 year old female presenting with longitudinally extensive transverse myelitis in the cervical region of the spinal cord two weeks post herpes zos...

journal_title：Multiple sclerosis and related disorders

authors： Mathew T,Thomas K,Shivde S,Venkatesh S,Rockey SM

更新日期：2017-11-01 00:00:00

abstract：:Neoplasms and reactivation of latent viruses have been observed in individuals taking fingolimod. Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer, is associated with immunosuppression and can be triggered by the oncogenic Merkel cell polyoma virus (MCPyV). We report a case of a 61-year-old man with mult...

journal_title：Multiple sclerosis and related disorders

authors： Mahajan KR,Ko JS,Tetzlaff MT,Hudgens CW,Billings SD,Cohen JA

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Infusion-associated reactions (IARs) occur in >90% patients with multiple sclerosis (MS) treated with alemtuzumab. We aimed to study the frequency of IARs at 2 sites using 5 days of steroids (1g/day of IV methylprednisolone), but otherwise distinct protocols. METHODS:This was retrospective chart review of 38...

journal_title：Multiple sclerosis and related disorders

authors： Šega-Jazbec S,Barun B,Horvat Ledinek A,Fabekovac V,Krbot Skorić M,Habek M

更新日期：2017-10-01 00:00:00

abstract：:Visual symptoms are a common clinical manifestation of multiple sclerosis (MS) and are frequently due to acute optic neuritis (ON). However, the entire visual pathway can be involved throughout the disease course. We describe the case of a young MS patient who experienced visual symptoms that were eventually found to ...

journal_title：Multiple sclerosis and related disorders

authors： Gaetani L,Iaccheri B,Cerquaglia A,Gentili L,Fiore T,Di Gregorio M,Mancini A,Calabresi P,Cagini C,Sarchielli P,Di Filippo M

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Multiple Sclerosis (MS) is a degenerative disease of central nervous system caused by an immune response against the myelin. About half of MS patients suffers from sleep disturbances. The circadian clock genes such as PER3 controls circadian rhythm and sleep. Due to the role of PER3 in sleep disturbances and...

journal_title：Multiple sclerosis and related disorders

authors： Golalipour M,Maleki Z,Farazmandfar T,Shahbazi M

更新日期：2017-10-01 00:00:00

abstract：:61-year-old woman with Neuromyelitis optica (NMO) diagnosis treated with rituximab was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein. She developed a multiple organ failure and died three hours later. W...

journal_title：Multiple sclerosis and related disorders

authors： Fuentes Fernandez I,Hernandez-Clares R,Carreón Guarnizo E,Meca Lallana JE

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:To examine the association between vagotomy and multiple sclerosis. METHODS:We conducted a matched cohort study of all patients who underwent truncal or super-selective vagotomy and a comparison cohort, by linking Danish population-based medical registries (1977-1995). Hazard ratios (HRs) for multiple scler...

journal_title：Multiple sclerosis and related disorders

authors： Sundbøll J,Horváth-Puhó E,Adelborg K,Svensson E

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Using spectral domain optical coherence tomography (SD-OCT), to compare the choroidal thickness in a healthy population (group 1), with newly diagnosed multiple sclerosis (MS) patients (group 2), with MS patients who underwent β-interferon monotherapy (group 3) and MS patients who underwent fingolimod therapy...

journal_title：Multiple sclerosis and related disorders

authors： Kal A,Oğuz Ulusoy M,Horasanlı B,Cezairlioğlu Ş,Kal Ö

更新日期：2017-05-01 00:00:00

abstract：AIM OF THE STUDY:To investigate adherence to disease modifying therapy (DMT) in Lithuanian population of multiple sclerosis patients and factors associated to it. METHODS:Patients receiving one of the following DMT's: Interferon β 1a (Rebif) 44 micrograms three times a week subdermally (s/c) or Interferon β 1a (Avonex...

journal_title：Multiple sclerosis and related disorders

authors： Duchovskiene N,Mickeviciene D,Jurkeviciene G,Dirziuviene B,Balnyte R

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Functional electrical stimulation (FES) is commonly used to ameliorate gait deficits in patients with multiple sclerosis (PwMS). This review critically evaluates the literature describing the orthotic and therapeutic effects of FES on gait in PwMS. METHODS:The PubMed, CINAHL, and ProQuest databases were sea...

journal_title：Multiple sclerosis and related disorders

authors： Springer S,Khamis S

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To investigate the predictive factors associated with good outcomes of plasma exchange in severe attacks through neuromyelitis optica spectrum disorder (NMOSD) and long extensive transverse myelitis (LETM). In addition, to review the literature of predictive factors associated with the good outcomes of plasma...

journal_title：Multiple sclerosis and related disorders

authors： Aungsumart S,Apiwattanakul M

更新日期：2017-04-01 00:00:00

abstract：:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder characterised by psychiatric symptoms, movement disorder and seizures often evolving into a severe encephalopathy. An overlap has recently been recognised between anti-NMDAR encephalitis and inflammatory demyelinating disorders, particul...

journal_title：Multiple sclerosis and related disorders

authors： Baheerathan A,Brownlee WJ,Chard DT,Shields K,Gregory R,Trip SA

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:All people with progressive MS in the United Kingdom should have access to physiotherapy through the National Health Service (NHS). However levels of access and delivery are unknown. Furthermore there is no research on perceived efficacy of physiotherapy or the use of complementary and alternative medicine...

journal_title：Multiple sclerosis and related disorders

authors： Campbell E,Coulter E,Mattison P,McFadyen A,Miller L,Paul L

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Patient-reported outcomes (PROs) provide information on treatment effects from the patient's perspective that complement outcomes on clinical measures. In DECIDE, daclizumab demonstrated superior efficacy in reducing relapses, 24-week confirmed disability progression, and brain lesions (assessed by magnetic ...

journal_title：Multiple sclerosis and related disorders

authors： Liu Y,Vollmer T,Havrdova E,Riester K,Lee A,Phillips G,Wang P,Sabatella G

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:People with multiple sclerosis (MS) often develop symptoms including muscle weakness, spasticity, imbalance, and sensory loss in the lower limbs, especially at the ankle, which result in impaired balance and locomotion and increased risk of falls. Rehabilitation strategies that improve ankle function may imp...

journal_title：Multiple sclerosis and related disorders

authors： Lee Y,Chen K,Ren Y,Son J,Cohen BA,Sliwa JA,Zhang LQ

更新日期：2017-01-01 00:00:00

abstract：:Herpes simplex virus encephalitis (HSE) is a rare but often fatal disease if left untreated. MRI typically shows the characteristic findings of medial temporal lobe and insular involvement, while diagnosis in confirmed by CSF PCR. In immunocompromised state, HSE may have atypical clinical and radiological features. We...

journal_title：Multiple sclerosis and related disorders

authors： Haggiag S,Prosperini L,Galgani S,Pozzilli C,Pinnetti C

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Visual dysfunction in MS can be quantified using a variety of tests. Many vision tests have not been formally evaluated among MS patients with existing visual dysfunction. OBJECTIVE:Evaluate several versions of visual acuity and contrast sensitivity tests, measures of central and peripheral vision, retina s...

journal_title：Multiple sclerosis and related disorders

authors： Longbrake EE,Lancia S,Tutlam N,Trinkaus K,Naismith RT

更新日期：2016-11-01 00:00:00

abstract：:Thrombotic microangiopathy (TMA) is a rare but increasingly recognized complication of interferon-beta therapy, which can be associated with serious sequelae. We report on a 53-year-old woman with a longstanding history of relapsing-remitting multiple sclerosis, who developed TMA after 15 years of high-dose treatment ...

journal_title：Multiple sclerosis and related disorders

authors： Gerischer LM,Siebert E,Janke O,Jungehuelsing GJ,Ruprecht K

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The prevalence of multiple sclerosis (MS) varies throughout the world, and available epidemiological data suggest a progressively increasing prevalence of MS in Spain. The objective of this study was to calculate MS prevalence in Health District III of the autonomous community of Murcia in Spain. METHODS:Th...

journal_title：Multiple sclerosis and related disorders

authors： Candeliere-Merlicco A,Valero-Delgado F,Martínez-Vidal S,Lastres-Arias Mdel C,Aparicio-Castro E,Toledo-Romero F,Villaverde-González R

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The role that dietary interventions can play in multiple sclerosis (MS) management is of huge interest amongst patients and researchers but data evaluating this is limited. Possible effects of a very-low-fat, plant-based dietary intervention on MS related progression and disease activity as measured by brain...

journal_title：Multiple sclerosis and related disorders

authors： Yadav V,Marracci G,Kim E,Spain R,Cameron M,Overs S,Riddehough A,Li DK,McDougall J,Lovera J,Murchison C,Bourdette D

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The appropriate treatment target in multiple sclerosis (MS) is unclear. Lack of magnetic resonance imaging (MRI) lesion activity, a component of the no evidence of disease activity concept, has been proposed as a treatment target in MS. We used our MS database to investigate whether aggressively pursuing MRI...

journal_title：Multiple sclerosis and related disorders

authors： Conway DS,Thompson NR,Cohen JA

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Fingolimod (FTY720) has been approved as the first oral representative of the class of sphingosine-1-phosphate (S1P) receptor modulators for the treatment of relapsing-remitting multiple sclerosis (MS). Besides inducing vaso-relaxation, fingolimod can also influence electrical conduction in the myocardium an...

journal_title：Multiple sclerosis and related disorders

authors： Meissner A,Limmroth V

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:We aimed to estimate the incidence and prevalence of chronic lung disease (CLD), including asthma and chronic obstructive pulmonary disease, in the MS population versus a matched cohort from the general population. METHODS:We used population-based administrative data from four Canadian provinces to identify...

journal_title：Multiple sclerosis and related disorders

authors： Marrie RA,Patten S,Tremlett H,Svenson LW,Wolfson C,Yu BN,Elliott L,Profetto-McGrath J,Warren S,Leung S,Jette N,Bhan V,Fisk JD

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Natalizumab is a monoclonal antibody that significantly reduces the occurrence of relapses in relapse-remitting multiple sclerosis (RRMS) patients. Early papers on the clinical use of natalizumab in RRMS patients reported erythroblastemia as occasional and transient. OBJECTIVES:to determine the prevalence a...

journal_title：Multiple sclerosis and related disorders

authors： La Gioia S,Seghezzi M,Barcella V,Dominoni P,Mecca T,Frigeni B,Conti MZ,Vedovello M,Vidali M,Rottoli M,Buoro S

更新日期：2016-07-01 00:00:00